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The aim of this review is to summarize the increasing list of roles of IGF-I, both in physiological and pathological conditions, underlying that its potential therapeutical options seem to be limited to those proven states of local or systemic IGF-I deficiency as a replacement treatment, rather than increasing its level upper the normal range

The lack of strong independent replication is a significant gap

If more than 24 hours have passed, skip the missed dose entirely and continue with the next scheduled administration rather than doubling up

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3,190,191,192 NAMPT was originally called pre-B-cell colony-enhancing factor (PBEF), a cytokine secreted by early B cells to promote maturation and proliferation