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CYP3A4 inhibition by ketoconazole yielded an IC 50 of 0.83 M in iHLOs, comparable to HepaRG cells (0.42 M) but less potent than the IC 50 (0.056 M) from PHHs, demonstrating their applicability for studying CYP-mediated drug-drug interactions (Fig

Generally age well and boost longevity: Exercise is important here, too, along with other healthy habits like following a well-rounded diet and making sure you get 7 to 9 hours of sleep per night

Immunometabolism: an emerging frontier

Identifying these individuals is essential for preventing deficiency and its associated complications