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It was reported that p53 could promote ferroptosis by repressing the expression of SLC7A11 in both transcriptional and non-transcriptional manners, which led to the decreased uptake of Cys2 and impaired GSH biogenesis[40, 41]

LPO has also been described following metHb binding to the membrane, suggesting that this linkage favors LPO [37]

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It is often given 12 times weekly for several months and paired with Glutathione for detoxification and neuroprotection

& Ralser, M