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evaluated a 2-week treatment with different doses of larazotide, ranging from 0.5 to 8 mg t.i.d., with daily gluten challenge in 86 celiac disease patients on a gluten-free diet (97)

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These new discoveries, together with the in-depth preclinical characterization of NAD + modulators and ongoing developments in their translation in humans, will open further avenues of study of this essential cofactor and its clinical therapeutic potential