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Vigorous supportive therapy is required in severe intoxication

A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

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10.1002/cpz1.776 Curr

This can be due to intrinsic factors within the red blood cells such as oxidative stress (Jilani 2011), or extrinsic factors such as an enlarged, overactive spleen (MedlinePlus 2011b)

Box 2-1 describes some of the experimental models that were used in the research described in this section to study the physiological response to brain injury in animal models