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10.12980/APJTB.4.2014C925 16 AlkhudhayriA.Abdel MoneimA

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Furthermore, a chronic inflammatory state in the nervous system intensifies with age, leading to increased microglial activation and elevated levels of proinflammatory cytokines, such as tumor necrosis factoralpha (TNF) and interleukin1 beta (IL1), detectable even preclinically [63, 64]