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however, the direct causal relationship requires further validation

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Likewise, circadian regulators (e.g., BMAL1/ARNTL degradation) and combined signatures (e.g., cuproptosisferroptosis or m6Am6A-ferroptosis panels) identify new vulnerabilities that can be targeted therapeutically

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For example, the inhibition of mTOR enabled TFEB dephosphorylation and translocation the later increased the expression of genes encoding lysosomal proteins, such as V-ATPases, lysosomal transmembrane proteins, and hydrolases 93

Lopez, E