While a healthy, intact BBB tightly restricts the movement of these substances into the CNS compartment, these, and other myeloid-responsive factors, such as cytokines, are not fully restricted from entering the CNS, which may compromise BBB integrity through stimulation of perivascular Ms and microglia
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In silico modelling suggests that rs146558 is a nonsynonymous single nucleotide polymorphism that leads to disruption in protein function
In animal studies, administration of BPC 157 following the damage caused by these drugs has shown that damage such as ventricular tachycardia, bradycardia, T wave elevation, QTc prolongation and asystole can be completely resolved in mice
This resolves after discontinuation
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