In senescent cells, disrupting this interaction causes p53 to translocate to the mitochondria, triggering apoptotic cell death specifically in aged, dysfunctional cells while sparing healthy ones [1]
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In vivo, rodent studies indicate that Epithalon reduces chromosomal aberrations in aging mice, which is a marker of genomic stability [3]
Cyclophosphamide , an alkylating agent, exerts its cytotoxicity by forming DNA cross-links and is used in breast cancer, lymphomas, and autoimmune malignancies
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