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This concern is a common theme in neurodegenerative disease treatment, when disease-modifying therapies are often considered to be effective only, or mainly, in the early stages of the degenerative process

The effect of 1-thyroxine on serum lipoprotein and cholesterol concentrations

These findings implicate CHAC2 in various cellular functions, including DNA replication and repair, cell cycle regulation, apoptosis, and stem cell differentiation, indicating that its functional repertoire is more versatile than initially presumed (Peng et al., 2023