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The practical research question is whether activating this pathway can reduce food intake and body weight without relying only on GLP-1 signaling

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DNA Cell Biol 39(8):14101420

The skin-specific mechanisms of GHK-Cu include stimulation of Type I and Type III procollagen synthesis, increased production of dermatan sulfate and other glycosaminoglycans, activation of the enzyme lysyl oxidase (which cross-links newly formed collagen), reduction of matrix metalloproteinase-1 (MMP-1, collagenase) activity, and anti-inflammatory suppression of TNF-alpha-induced IL-6 secretion

In: Chauhan A, Chauhan V, Brown WT, editors

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