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GHK-Cu also modulates gene expressionupregulating genes associated with tissue repair while downregulating inflammatory and fibrotic pathways

2016;113(8):E96877

ACSL4, acyl-CoA synthetase long chain family member 4

in these cultured cells cotreatment of klotho and bFGF further increased ERK1/2 phosphorylation, while inhibition of ERK1/2 activation leads to abolition of klotho-induced GH release in normal pituitaries (102)

[33] investigated the antidepressant mechanism of CSS and found that CSS treatment significantly reversed CUMS-induced alterations in phosphorylated phosphoinositide 3-kinase (PI3K) and phosphorylated protein kinase B (AKT) expression, while decreasing glycogen synthase kinase-3beta (GSK3) expression, suggesting that the PI3K/AKT/GSK3 pathway may be involved in the antidepressant effects of CSS

Wiktelius, E