Modulating chaperone-mediated autophagy and its clinical applications in cancer
The medical treatment of Parkinson disease from James Parkinson to George Cotzias
Kennedy has made the same case, arguing that compounding would pull people away from a dangerous black market that puts Americans at risk. Jerome Adams, the 20th Surgeon General, argued in STAT this month for a middle path, letting licensed pharmacies compound selected peptides under clinician supervision with mandatory disclaimers and outcome tracking, instead of choosing between a free-for-all and a ban
Most peptides cannot cross cell membranes on their own, which limits their usefulness as topical treatments
J Biol Chem 287:2299823009 Ishikawa Y, Vranka JA, Boudko SP, Pokidysheva E, Mizuno K, Zientek K, Keene DR, Rashmir-Raven AM, Nagata K, Winand NJ, Bachinger HP (2012) Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding
Yao Y, Chen Z-L, Norris EH, Strickland S