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The SURMOUNT-1 trial in participants without diabetes showed even more impressive results, with some dose groups achieving over 22% average weight reduction

Conventional therapeutic approaches which include rehabilitation exercises, medications and operative procedures such as spinal fusion, disc arthroplasty focus predominantly on symptom management without addressing the fundamental degenerative cascade [45]

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We thank the staff of the European Synchrotron Radiation Facility (beamlines ID14-4 and ID 29) for provision of synchrotron radiation facilities and assistance

[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Lash L.H