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This particular arrangement was first isolated and characterized in 1993 by researchers at the University of Zagreb, Croatia, led by Dr

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315,316,317,318 In AD, enhanced activity of L-type VGCCs, potentially related to their interaction with A/tau, promotes excessive calcium influx into cells

The compound incorporates three non-standard structural features: an -aminoisobutyric acid (Aib) at the N-terminus bearing no stereocenter, a D-2-naphthylalanine (D-2-Nal) at position 3, and a D-phenylalanine at position 4

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