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10.1186/s12974-019-1676-0 J

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By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects

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They decrease pro-inflammatory cytokines such as TNF- and IL-6 and promote reparative M2 macrophage phenotypes that reduce fibrosis and maintain tissue architecture

Nicotinamide riboside (NR) is a precursor that the body converts into NAD+, while NAD+ is the final form used in cellular processes