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The 44% reduction in histological degeneration scores is a clinically meaningful finding

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Proc Natl Acad Sci U S A 99:1190813 Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S (2009) Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

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Without this signal, the body readily sacrifices muscle as part of the weight loss process, leaving men lighter but not meaningfully leaner