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Fluctuating serotonin levels have recently been implicated in the after-effects of STN DBS due to data reporting that (1) cognitive and depressive symptoms develop after stimulation and (2) anti-Parkinsonian drugs reduce serotonin in the prefrontal cortex and hippocampus, and (3) selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine enhance responsiveness to neurostimulation [371,373,373]

Chappell D, Jacob M, Hofmann-Kiefer K, Bruegger D, Rehm M, Conzen P, Welsch U, Becker BF

Though the cluster of cellular responses to stress was detected in both tissue types, overrepresented pathways differ

Cells were aliquoted and stored at 180 C until use

( c - e ) Pathway enrichment analysis of liver transcriptomes

J Clin Neurosci 71:2631 Manroa P, Kannan S, Hatipoglu B, Licata A (2014) Hypercalcemia and acromegaly--clarifying the connections