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the hypothesized linkage between the action of AngFV analogues and the HGF/c-Met system predicted that like Dihexa and Nlel -AnglV HGF should be able to stimulate dendritic spine growth in dissociated hippocampal neurons

Blood-Brain Barrier Penetration and CNS Distribution Achieving sufficient CNS concentrations is a critical pharmacokinetic requirement for a procognitive compound, and Dihexa's peptidomimetic design addresses this challenge

In the absence of GPx4 activity, lipid peroxides accumulate within cellular membranes

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Additionally, inflammatory conditions are also suggested to benefit due to its regenerative and protective properties

Liver function tests (LFTs) in toxicological studies revealed significantly higher globulin and AST levels in the chronic group, though other LFT markers were unaffected