Monitoring and management of AEs are essential to promoting therapy persistence
Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival
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found that through ROS-mediated activation of the PI3K/Akt signaling pathway, HIF-1 was up-regulated in cancer cells, inducing glucose metabolic reprogramming, and eventually cancer cells acquire resistance to anti-tumor drug (108)
doi: 10.1038/s41579-023-00960-9 251 LockhartS