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The functionalization usually provides with colloidal stability, allows for stearic or electrostatic binding with the active therapeutic drug, targeting moieties, or the imaging probe, and tuning important properties of pharmacokinetics, systemic toxicity, clearance, cellular interactions, and non-specific protein absorptions [5, 16, 123, 206,207,208,209,210,211,212,213,214,215]

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