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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

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An epoxide ring is attached to the tetrahydropyran ring and overall, this core structure is referred to as the 12,13-epoxytrichothec-9-ene (EPT) nucleus

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Annual Meeting of the Society of University Surgeons