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The committee will evaluate DSIP for opioid withdrawal, chronic insomnia, and narcolepsy and consider it for the Section 503A Bulk Drug Substances List

0.25 mg per injection Weeks 1 4 Frequency 1 / week Monthly Total 1.0 mg Purpose GI adaptation 0.25 mg/wk 0.5 mg per injection Weeks 5 8 Frequency 1 / week Monthly Total 2.0 mg Purpose Dose escalation 0.5 mg/wk 1.0 mg per injection Weeks 9 12 Frequency 1 / week Monthly Total 4.0 mg Purpose Therapeutic range 1.0 mg/wk 1.7 mg per injection Weeks 13 16 Frequency 1 / week Monthly Total 6.8 mg Purpose Continued escalation 1.7 mg/wk 2.4 mg per injection Week 17 onward Frequency 1 / week Monthly Total 9.6 mg Purpose Maintenance dose 2.4 mg/wk Pick Your Injection Day Cagrilintide is injected once per week on the same day

10.1073/pnas.97.2.571 Proc

Ribari, M

DSIP (Delta Sleep-Inducing Peptide) is studied for its role in sleep regulation, cortisol normalization, circadian rhythm modulation, and neurological recovery

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