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All experimental protocols were approved by the Institutional Commission for the Care and Use of Laboratory Animals (CICUAL), Instituto de Ciencia y Tecnologa Dr

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232 In a placebo-controlled trial in 46 patients with generalized anxiety disorder, the addition of L-theanine, at doses of 450900 mg per day, to antidepressant therapy for eight weeks improved sleep satisfaction and reduced severity of insomnia in those with mild sleep-related symptoms