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Mitochondrial dysfunction in bipolar depression There has been a recent conceptualization of BD as a mitochondrial disorder, with the suggestion that energy production is increased in mania and decreased in the depressive phase [30, 31]

Glutathione helps protect neurons and may play a role in preventing cognitive decline

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Oxidation of cysteine residues can result in a wide range of redox-based, post-translational modifications, including S-nitrosylation, S-glutathionylation and sulfinic acid, sulfenic acid and disulfide formation 22,23 , which can generate conformational changes in protein structure and subsequent modulation of protein activity 24