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In vitro evidence demonstrated that propionate upregulated gluconeogenic rate-limiting enzymesincluding phosphoenolpyruvate carboxykinase 2 (PEPCK2) and fructose-1,6-bisphosphatase 1 (FBP1)within jejunal epithelial cells, thereby supporting local mucosal energetics 74

Yet, some procarcinogens require phase I enzymes in order to become active carcinogens capable of binding DNA and forming cancer-causing DNA adducts

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