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Peripherally, KynA has been shown to reduce stress-induced colitis in mice by promoting NLRP3 inflammasome autophagy, demonstrating the pervasive impact of this metabolite [122]

It helps "recharge" spent glutathione molecules so they can continue fighting free radicals

Lets take a look at a few animal studies as examples: Adding stress hormones causes mitochondrial dysfunction: The addition of corticosterone in mice will cause depression, and this is one way of making a mouse model of depression

Suzuki A, Xiao L, Taketa T, Sudo K, Blum MA, Komaki R, Liao ZX, Lee JH, Bhutani MS, Weston B, Hofstetter WL, Swisher S