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Rhythmic daily oscillations in both circulating innate and adaptive immune cells, and in cytokine and chemokines occur in the healthy brain (Labrecque and Cermakian, 2015), and circadian clock disruptions dysregulate immune response (Comas et al., 2017) and alters circulating proinflammatory cytokines, complement factors, and oxidative stress (Shivshankar et al., 2020)

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doi: 10.1074/jbc.M408893200 225 GongYWangNLiuN