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The JAK/STAT signaling pathway, as the main target for inhibiting the action of a variety of cytokines (221), is involved in the signal transduction of many key cytokines for the pathogenesis of RA and has been considered as a potential target for the treatment of RA (222)

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doi: 10.1200/JCO.2000.18.3.562 20 LiuXMengQHYeYHildebrandtMATGuJWuX

User 15 cited a general dosing range of 2.5 to 3.75mcg per kilogram of body weight twice daily, which, at higher body weights, still produces doses within the standard 250 to 500mcg range being used across the dataset

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Activated JNK facilitates the translocation of pro-apoptotic proteins Bax and Bak to the mitochondria and simultaneously inhibits the anti-apoptotic activity of Bcl-xL, thereby indirectly triggering the mitochondrial apoptotic pathway