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Carrying out this initial gradient purification step allows the bead purification by negative selection to be performed more efficiently

CagriSema (cag + sema) is the closest analog with human trial data

Sallinen, H., Putaala, J

Ekstrand, M

C5 inhibitor treatment complement inhibitor treatment Side effects (5%) in patients treated with EMPAVELI in the PEGASUS study vs eculizumab The following reactions were mild or moderate in severity: diarrhea, fatigue, fever, viral infections, and injection site reactions Serious adverse reactions were reported in 17% of patients treated with EMPAVELI The most common serious adverse reaction was infections (5%) Breakthrough hemolysis occurred in 10% of those taking EMPAVELI vs 23% of those taking eculizumab at Week 16 in the PEGASUS study

BioRxiv [Preprint]