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Historically only two of these criteria could be accomplished with a high degree of execution, with the third being sacrificed due to physical constraints of the delivery system architecture

72 To a solution of isophorone (691 mg, 5 mmol) and malononitrile (429 mg, 6.5 mmol) in anhydrous EtOH (10 mL) was added piperidine (60 L, 0.6 mmol) and glacial acetic acid (34 L, 0.6 mmol) under an argon atmosphere

RT was performed with the High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific)

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