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2 A separate 2-week RCT testing three GlyNAC dose levels in 114 healthy older adults found good tolerability but no significant improvement in the primary endpoint (GSH:GSSG ratio) in the full study population, highlighting that responses may depend on baseline oxidative stress levels and study duration

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By reducing oxidative stress and stabilizing mitochondrial membranes, SS-31 enhances mitochondrial function, potentially mitigating heart failure and improving cardiac energy metabolism

doi: 10.1142/S0192415X18500246 44

Reducing USP9X lowered the expression of BMAL1 target genes PER2 and CRY1 in mouse neuroblastoma cells, but in U2OS cells, knockdown only slightly reduced rhythm amplitude without changing the period (Zhang et al., 2018)