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This study addresses, for the first time, the involvement of UBE3A in mitochondrial function during the embryonic development of Angelman syndrome, and the critical role of ROS in controlling the fate of neural stem and progenitor cells in AS brain development

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and Methanobrevibacter , which increase intraluminal pressure and decrease peristaltic movements, leading to constipation [136]

18 No similar improvement was observed in a human trial looking at depression

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