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Across all diagnostic frameworks, fatigue constitutes the mandatory core symptom, with a required duration of at least 3 to 6 months

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All three of these vitamins are also required for glutathione synthesis

[1] This phenomenon appears to be an indirect consequence of the medication's primary therapeutic effects rather than a direct pharmacological action on temperature regulation

While a constant exposure of quinone is not necessarily representative of an in vivo scenario, it is however, much more representative of an in vitro situation, whereby a constant source of quinone is essentially available in the extracellular media during cell culture 27