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[92] A one-carbon (1C) methyl group is added to tetrahydrofolate through the action of serine hydroxymethyltransferase (SHMT) to yield 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF)

(A) Calcein AM cell viability assay after 24 hour exposure of 20 M IAA with co-treatment of (A) MB, (B) 2-chlorophenothiazine (C) NR, or (D) chlorpromazine

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Corticosteroid and NAC nasal douching significantly reduced symptom severity more than two-fold, resolved mucosal edema, and restored mucociliary function in recurrent acute rhinosinusitis patients compared to steroid with ambroxol, leading to better long-term satisfaction (121)