To compensate for this sudden loss of blood pressure, the autonomic nervous system triggers severe tachycardia (a rapid heart rate), manifesting as Postural Orthostatic Tachycardia Syndrome (POTS) and other forms of dysautonomia
Collectively, these late effects illustrate the narrow therapeutic window inherent to brachytherapy: the difference between a curative dose and the threshold for debilitating toxicity is small, particularly in patients with complex pelvic anatomy or advanced disease
The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules)
Clin Drug Investig 2009
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