At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity
Costs vary by provider, but if you buy vitamin B12 injections online through Hone, the shots cost $60 per month
Can vitamin injections promote healthy weight gain
If your levels are exceptionally low (which can be determined by a blood test), your GP might offer you a vitamin B injection
However, there is little to no evidence to support these claims
This is especially important if you have a high homocysteine level over 9 or have been tested to have low B12 or folate levels
