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The same reduced-IGFBP-binding property that produces enhanced in vivo potency in animal studies also produces enhanced cell-culture activity, because the IGFBPs secreted into serum-free media by cultured cells otherwise reduce the bioavailability of native IGF-1 supplementation

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that MPO was associated with cannabis use and comorbid MDD and that TIMP-1 was elevated among PTSD participants who endorsed SSRI use