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Correlation coefficients, where reported, are Pearsons Rho (for normally distributed variables) or Spearmans rank correlation coefficient (for non-normally distributed variables)

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For adults over 65, no dose adjustment is required, but careful monitoring for adverse effects is prudent as older adults often have multiple comorbidities and medications that increase complication risk

doi: 10.1517/14656566.3.10.1481

Although the mechanism is still unclear, glyoxylate was reported to inhibit RuBP regeneration and rubisco activation 37,38,39,40,41 and therefore is toxic to plants