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Many promising biomarkers identified in small studies fail to replicate in larger validation cohorts

This step leads to activation of these compounds to their reactive electrophilic metabolites with potential mutagenic and cancerogenic effect

Growth is delayed, resulting in reduced weight, height, and head circumference

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It also appears to support angiogenesis and counteract the negative effects of corticosteroids on healing. However, despite over two decades of preclinical research, there is a paucity of clinical trials evaluating its use for musculoskeletal injuries in humans, and it remains unapproved for medical use by regulatory bodies. Collagen peptides do have human clinical data