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Nature 485 , 661665 (2012)

Although ultrasonography has enabled the in situ evaluation of 1D profile of solid stresses within glioblastoma tumors [111], the estimation of both the isotropic and anisotropic components of the stress tensor exerted on cells and tissues remained elusive until recently

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The advisory committee's recommendation is not binding, but historically the FDA adopts PCAC vote outcomes in its final 503A bulk substance determinations