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16 Additional genetic alterations, including frameshift mutations in ATG2B, ATG5, ATG9B , and ATG12 17 as well as cancer-specific splicing variants of ATG5 , further impair autophagy and contribute to tumor initiation

just producing way too much stomach acid

Naidu KA, Thippeswamy NB

Studied in models involving antioxidant defense, oxidative stress response, and cellular redox balance