In the AMY 1 R and AMY 3 R Y37 rAmy interacts with residues in the respective RAMP and the CTR ECD, however the small side chain of P37 Cagri is completely buried by the surrounding CTR ECD residues, forming extensive hydrophobic contacts with W79 ECD and no direct interactions with either RAMP1 (AMY 1 R) or RAMP3 (AMY 3 R), again consistent with the restrictive interactions formed by Pro32 sCT with the CTR ECD
Antioxidants (2021) 10(10):1555
J Pharm Pract
Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Mood Disorders & Maintaining Mental Health (Protocol 1) (00:07:10) Sponsors (00:11:15) Major Depression (00:18:40) Anti-Self Confabulation (00:21:42) Autonomic (Vegetative) Symptoms of Depression (00:26:58) Norepinephrine, Dopamine & Serotonin (00:31:50) SSRIs (Prozac, Zoloft, etc.): Selective Serotonin Reuptake Inhibitors (00:37:00) Epinephrine/Motor Functions, Dopamine/Motivation & Craving, Serotonin/Emotions (00:39:33) Physical & Emotional Pain are Linked: Substance P (00:41:50) Hormones & Depression: Thyroid & Cortisol (00:46:50) Genetic Susceptibility to Depression: Impact of Stress (00:50:50) Understanding Biological Mechanism Is Key: Recipes versus Skills (00:52:50) Tools for Dealing with Depression: Logic & Implementation (Protocol 2) (00:56:25) Brain Inflammation & Mental State: Cytokines, Prostaglandins, etc
The addition of BPC-157 and TB-500 theorizes a faster, more robust restructuring of the dermal-epidermal junction
IPL-useful for post acne redness Fractional Co2/Erbium Yag useful for acne scars Microneedling with PRP (Vampire Facial) stimulates collagen production, improving acne scars
