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This corresponds with other studies that suggest a decreased HRV is present in ME/CFS, indicative of a chronically high sympathetic tone (78, 330, 332344)

In terms of targeting, extracellular vesicles have corresponding ligands on their surface, and through surface binding and endocytosis, they naturally have a delivery advantage (Han et al., 2021b

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Some addiction recovery programs utilize NAD+ infusions to potentially help alleviate withdrawal symptoms and cravings, as NAD+ is thought to aid brain-cell recovery in substance use disorders

Liu Y, Zhou Q, Tang M et al (2015) Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinsons disease