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2021 May 12;16(1):215

10.1016/j.bbamcr.2025.119934 140 XiangM.YuanX.ZhangN.ZhangL.LiuY.LiuJ.et al (2024)

In liver of obese diabetic mice, FGF21 reduces oxidative damage and lipid peroxidation (152)

While its true that receptor density can change due to various factors, its an oversimplification to suggest that this change is the direct cause of increased pain or sensations in B12-treated individuals