10.1021/nn403096s 22 KostJ.LangerR
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Higher retatrutide doses (10-12 mg) produce more GI side effects and carry a higher risk of dysesthesia (tingling/numbness) without engaging the amylin pathway
Among the 8 identified metabolites, the levels of L-acetylcarnitine, L-carnitine, ribonic acid, and glucaric acid tended to increase from stage 1 and became significantly higher in stage 3 when compared to controls (Fig
The median time to onset of any-grade hepatic events (29.0 d), diarrhea/colitis (63.0 d), dermatitis/rash (144.0 d), and endocrine events (113.0 d) for participants who received durvalumab monotherapy in our study occurred earlier than in a real-world study of atezolizumab plus bevacizumab in advanced HCC, where the median time to onset of any-grade hepatic, gastrointestinal, dermatologic, and endocrine events was 96.0, 124.0, 168.0, and 133.0 days, respectively
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