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To uncover the trigger of glucose deprivation-induced cell death by -KG limitation, we treated shCtrl and shGDH1 cells with reactive oxygen species (ROS) scavengers including N -acetylcysteine (NAC), tempol and Trolox 28

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In cancer treatment, some widely used chemotherapeutic drugs (such as cisplatin, doxorubicin, arsenic trioxide (As 2 O 3 ), paclitaxel) enhance the apoptosis of cancer cells by inducing the production of intracellular ROS, prompting tumor cells to lose their ability to survive in an oxidative stress environment [466, 467]

Cogliati, S