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Oral, BBB-penetrant delivery: The medicinal-chemistry program characterized Dihexa as metabolically stable and orally active enough to reach the brain in animals the property that distinguished it from earlier AngIV peptides [1]

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Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (41, 62, 63)