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Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimers disease

Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

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Further genetic studies revealed the Past-time (Psttm) mutation in FBXL21 shortens circadian period and counteracts the long-period phenotype of FBXL3 (Ovtm) , illustrating their functional antagonism (Yoo et al., 2013)

doi: 10.1136/bmjopen-2018-024954 128 KuanY-CHuangK-WLinC-LHuC-JKaoC-H

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