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Moreover, stem-cell-based treatment is still associated with multiple concerns, such as poor cell survival, immune rejection, complex cell culture procedures, decreased regeneration capacity after transplantation, and ethical concerns 17,18

Currently used in vitro assays do not adequately predict in vivo observed effects, predominantly due to an inadequate preservation of the organs microenvironment in the models applied

Among these, peptide injections and platelet-rich plasma (PRP) therapy have gained attention for their potential to accelerate healing in muscle and tendon injuries

Unfortunately, this can result in poor outcomes for patients who have to deal with ongoing pain, discomfort, and follow-up procedures